Participants whose data were examined were 63% female, and more than 96% were white adults.

Researchers analyzed mortality data and medical records for more than 100,000 adults gathered from two large prospective studies: the all-female Nurses' Health Study and the all-male Health Professionals Follow-up Study from 1988-2018. 'Our study leveraged repeated measures of self-reported physical activity over decades to examine the association between long-term physical activity during middle and late adulthood and mortality.' 'The potential impact of physical activity on health is great, yet it remains unclear whether engaging in high levels of prolonged, vigorous or moderate intensity physical activity above the recommended levels provides any additional benefits or harmful effects on cardiovascular health,' said Dong Hoon Lee, Sc.D., M.S., a research associate in the department of nutrition at the Harvard T.H. The American Heart Association's current recommendations, which are based on HHS's Physical Activity Guidelines, are for at least 150 minutes per week of moderate-intensity aerobic exercise or 75 minutes per week or vigorous aerobic exercise, or a combination of both. In 2018, the United States Department of Health and Human Services' Physical Activity Guidelines for Americans recommended that adults engage in at least 150-300 minutes/week of moderate physical activity or 75-150 minutes/week of vigorous physical activity, or an equivalent combination of both intensities. It is well documented that regular physical activity is associated with reduced risk of cardiovascular disease and premature death.

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